Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:1522960 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1522960153801315054conserved repeat domain proteinQuickGO ontologyBLASTP
15381451538996852acetyltransferase GNAT familyQuickGO ontologyBLASTP
15390371539597561isochorismatase family proteinQuickGO ontologyBLASTP
15397791540039261hypothetical proteinBLASTP
15400421540953912transporter EamA familyQuickGO ontologyBLASTP
15409611541347387ribonuclease HQuickGO ontologyBLASTP
15414171542289873putative lacX proteinQuickGO ontologyBLASTP
15424731542958486hypothetical proteinBLASTP
15431021543761660hypothetical proteinBLASTP
15437741543950177hypothetical proteinBLASTP
15439841544232249hypothetical proteinBLASTP
15443521544549198cold shock protein CspBQuickGO ontologyBLASTP
15448121545540729hypothetical proteinBLASTP
15456111546312702hypothetical proteinBLASTP
15463321546625294hypothetical proteinBLASTP
15467051547334630fatty acid hydroxylase-like proteinQuickGO ontologyBLASTP
15475581547899342hypothetical proteinBLASTP
154790215494521551sodiumsolute symporter family proteinQuickGO ontologyBLASTP