Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:1334000 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
133509913364421344potassium uptake protein TrkH familyQuickGO ontologyBLASTP
13364761336841366hypothetical proteinBLASTP
13370741337541468hypothetical proteinBLASTP
13376261337739114hypothetical proteinBLASTP
13380921338340249hypothetical proteinBLASTP
13384581338697240hypothetical proteinBLASTP
13387571338993237hypothetical proteinBLASTP
13391131340009897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
134031613420251710acetolactate synthase catalytic subunitQuickGO ontologyBLASTP
13420221342531510acetolactate synthase 3 regulatory subunitQuickGO ontologyBLASTP
134255813435681011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
1343570134509015212-isopropylmalate synthaseQuickGO ontologyBLASTP
1345168134623210653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
134623213476261395isopropylmalate isomerase large subunitQuickGO ontologyBLASTP
13476041348185582isopropylmalate isomerase small subunitQuickGO ontologyBLASTP
134849613497581263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
13497341350369636ATP phosphoribosyltransferase catalytic subunitQuickGO ontologyBLASTP
135038113516701290histidinol dehydrogenaseQuickGO ontologyBLASTP
13516701352254585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
13522551352884630imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
135285713535767201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
13535701354328759imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
13546411354964324phosphoribosyl-ATP pyrophosphataseQuickGO ontologyBLASTP
135497613559921017histidinol-phosphataseQuickGO ontologyBLASTP
13560601356227168hypothetical proteinBLASTP