Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:1103737 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11037371104393657putative S-layer proteinQuickGO ontologyBLASTP
110457711061661590malate synthaseQuickGO ontologyBLASTP
110619011074671278isocitrate lyaseQuickGO ontologyBLASTP
11076411108429789trifolitoxin immunity domain proteinQuickGO ontologyBLASTP
11087811108984204cold shock protein CspAQuickGO ontologyBLASTP
11090861109361276hypothetical proteinBLASTP
11093871109572186hypothetical proteinBLASTP
11098541110435582putative competence transcription factorQuickGO ontologyBLASTP
11107091111302594hypothetical proteinBLASTP
11113591111922564signal peptidase IQuickGO ontologyBLASTP
111203911155543516ATP-dependent nuclease subunit BQuickGO ontologyBLASTP
111555111192763726ATP-dependent nuclease subunit AQuickGO ontologyBLASTP
11192891119576288hypothetical proteinBLASTP
11196141119829216spore germination protein GerPFQuickGO ontologyBLASTP
11198721120258387spore germination protein GerPEQuickGO ontologyBLASTP
11202741120468195spore germination protein GerPDQuickGO ontologyBLASTP
11204751121089615spore germination protein GerPCQuickGO ontologyBLASTP
11211561121362207spore germination protein GerPBQuickGO ontologyBLASTP
11213771121598222spore germination protein GerPAQuickGO ontologyBLASTP
11221121123020909fumarylacetoacetate hydrolase family proteinQuickGO ontologyBLASTP
11230561123340285hypothetical proteinBLASTP
112344611246361191ornithine--oxo-acid transaminaseQuickGO ontologyBLASTP
11247871125152366hypothetical proteinBLASTP
11252111125765555hypothetical proteinBLASTP
112600411278511848asparagine synthetase glutamine-hydrolyzingQuickGO ontologyBLASTP