Pre_GI Gene

Some Help

Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:1008028 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10080281009005978glyoxylase family proteinQuickGO ontologyBLASTP
100922910103411113TPR domain proteinQuickGO ontologyBLASTP
10103381010469132hypothetical proteinBLASTP
10106971011572876hydrolase alphabeta fold familyQuickGO ontologyBLASTP
10117131011853141hypothetical proteinBLASTP
10120271012878852hypothetical proteinBLASTP
10132381013687450hypothetical proteinBLASTP
10137851014345561glycerol uptake operon antiterminator regulatory proteinQuickGO ontologyBLASTP
10145741015395822glycerol uptake facilitator proteinQuickGO ontologyBLASTP
101540910168991491glycerol kinaseQuickGO ontologyBLASTP
101703310187151683glycerol-3-phosphate dehydrogenase aerobicQuickGO ontologyBLASTP
10189131019077165hypothetical proteinBLASTP
10195251019935411hypothetical proteinBLASTP
10201901020723534RNA polymerase factor sigma CQuickGO ontologyBLASTP
10207281021135408lineage-specific thermal regulator proteinQuickGO ontologyBLASTP
102114310223931251cell division protein FtsWRodASpoVE familyQuickGO ontologyBLASTP
10224511022936486transcriptional regulator MarR familyQuickGO ontologyBLASTP
10232211023586366hypothetical proteinBLASTP
102374810251391392major facilitator family transporterQuickGO ontologyBLASTP
102516210266101449drug resistance transporter EmrBQacA familyQuickGO ontologyBLASTP