Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:99899 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
998991012361338MATE efflux family proteinQuickGO ontologyBLASTP
101380101952573uracil-DNA glycosylaseQuickGO ontologyBLASTP
101981102415435MarR family transcriptional regulatorQuickGO ontology
1027971047341938methionyl-tRNA synthetaseQuickGO ontologyBLASTP
1048991064041506hypothetical proteinBLASTP
106555107349795TatD family hydrolaseQuickGO ontologyBLASTP
10757710863510593DG5 domain-containing proteinQuickGO ontologyBLASTP
108708109253546putative primaseQuickGO ontologyBLASTP
109255110082828dimethyladenosine transferaseQuickGO ontologyBLASTP
1101611114561296hypothetical proteinBLASTP
111615112202588hypothetical proteinBLASTP
112370113203834putative lipoproteinQuickGO ontologyBLASTP
1133711144321062putative macrolide efflux transporter RND family MFP subunitQuickGO ontologyBLASTP
114443115138696putative macrolide efflux ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
116425117267843putative MRP proteinQuickGO ontologyBLASTP
117413117604192iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
117619117723105hypothetical protein
118050118226177hypothetical protein
1183041193741071putative diguanylate cyclaseQuickGO ontologyBLASTP