Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:545840 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
545840546742903D-alanine--D-alanine ligaseQuickGO ontologyBLASTP
5468995480411143putative high-affinity branched-chain amino acid ABC transporter amino acid-binding proteinQuickGO ontologyBLASTP
548045548917873high-affinity branched-chain amino acid ABC transporter permeaseQuickGO ontologyBLASTP
548918549862945putative high-affinity branched-chain amino acid ABC transporter permeaseQuickGO ontologyBLASTP
549874550611738putative high-affinity branched chain amino acid ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
550613551314702putative high-affinity branched chain amino acid ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
551343552119777hypothetical proteinBLASTP
552521553279759hypothetical proteinBLASTP
553273553716444hypothetical proteinBLASTP
5538595553101452GntR family transcriptional regulatorQuickGO ontologyBLASTP
555371555940570lemA family proteinQuickGO ontologyBLASTP
555950556786837putative lipoproteinQuickGO ontologyBLASTP
557305558165861hypothetical proteinBLASTP
558328559221894NUDIX family hydrolaseQuickGO ontologyBLASTP
559355559837483hypothetical proteinBLASTP
560013560537525hypothetical proteinBLASTP
560539561129591putative methlytransferaseQuickGO ontologyBLASTP
561215561454240hypothetical proteinBLASTP
561475561936462hypothetical proteinBLASTP
5623705635991230exonuclease SbcCD subunit DQuickGO ontologyBLASTP
5635745671043531exonuclease SbcCD subunit CQuickGO ontologyBLASTP