Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:3744000 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37441753744852678putative transaldolaseQuickGO ontologyBLASTP
37448713745518648haloacid dehalogenaseQuickGO ontologyBLASTP
37455423746327786sorbitol-6-phosphate dehydrogenaseQuickGO ontologyBLASTP
37463473746712366PTS system glucitolsorbitol-specific transporter subunit IIAQuickGO ontologyBLASTP
374692837479321005PTS system glucitolsorbitol-specific transporter subunit IIBCQuickGO ontologyBLASTP
37479453748490546PTS system glucitolsorbitol-specific transporter subunit Iic transporter subunitQuickGO ontologyBLASTP
37485333748928396glucitol operon activator proteinQuickGO ontologyBLASTP
374894237499911050putative L-iditol 2-dehydrogenaseQuickGO ontologyBLASTP
37500263750997972putative glucitol operon regulatorQuickGO ontologyBLASTP
375135437527031350phosphoglucosamine mutaseQuickGO ontologyBLASTP
37533703754119750putative 2-oxoacidacceptor oxidoreductase subunit betaQuickGO ontologyBLASTP
3754119375518910712-ketoisovalerate ferredoxin reductaseQuickGO ontologyBLASTP
37552053755414210putative 2-oxoacidacceptor oxidoreductase subunit deltaQuickGO ontologyBLASTP
37555163756178663hypothetical proteinBLASTP
375644137575111071butyrate kinaseQuickGO ontologyBLASTP
37575403758451912phosphate butyryltransferaseQuickGO ontologyBLASTP
375844437595381095butyrate kinaseQuickGO ontologyBLASTP
375963937612371599FAD-binding oxidoreductaseQuickGO ontologyBLASTP
376123937625191281hypothetical proteinBLASTP
37624893763337849hypothetical proteinBLASTP