Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:35500 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3562636318693sugar fermentation stimulation protein AQuickGO ontologyBLASTP
3637436862489NUDIX family hydrolaseQuickGO ontologyBLASTP
3698037702723hypothetical proteinBLASTP
3783638624789iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
3864338804162hypothetical proteinBLASTP
3918739891705thiF domain-containing proteinQuickGO ontologyBLASTP
39974410831110major facilitator superfamily proteinQuickGO ontologyBLASTP
4111242056945GNAT family acetyltransferaseQuickGO ontologyBLASTP
47172472881175S ribosomal RNAQuickGO ontologyBLASTP
4757548171597uracil-DNA glycosylase family proteinQuickGO ontologyBLASTP
4818948305117hypothetical protein
53827539431175S ribosomal RNAQuickGO ontologyBLASTP
5438054943564RNA polymerase factor sigma-70QuickGO ontologyBLASTP
54940563821443hypothetical proteinBLASTP
61756618721175S ribosomal RNAQuickGO ontologyBLASTP
6325363366114hypothetical proteinBLASTP
68816689321175S ribosomal RNAQuickGO ontologyBLASTP
6915669899744peptidil-prolyl isomerase family proteinQuickGO ontologyBLASTP
75150752661175S ribosomal RNAQuickGO ontologyBLASTP
7563976382744NAD-dependent deacetylaseQuickGO ontologyBLASTP
7656877476909LD-carboxypeptidase family proteinQuickGO ontologyBLASTP
7751278453942transporter CorA metal ion transporter familyQuickGO ontologyBLASTP