Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:3126108 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
312610831287532646magnesium-translocating P-type ATPaseQuickGO ontologyBLASTP
31294403129844405hypothetical proteinBLASTP
313016631314071242phosphoribosylamine--glycine ligaseQuickGO ontologyBLASTP
313145931329581500bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferaseIMP cyclohydrolaseQuickGO ontologyBLASTP
31331843133801618phosphoribosylglycinamide formyltransferaseQuickGO ontologyBLASTP
31339283134923996phosphoribosylaminoimidazole synthetaseQuickGO ontologyBLASTP
313498431364321449amidophosphoribosyltransferaseQuickGO ontologyBLASTP
31365243137228705phosphoribosylaminoimidazole-succinocarboxamide synthaseQuickGO ontologyBLASTP
31372283137707480phosphoribosylaminoimidazole carboxylase catalytic subunitQuickGO ontologyBLASTP
313834831409032556xanthine dehydrogenase family protein molybdopterin-binding subunitQuickGO ontologyBLASTP
314126031424771218peptidaseQuickGO ontologyBLASTP
314250331438311329putative chlorohydrolaseaminohydrolaseQuickGO ontologyBLASTP
314386231468793018putative selenate reductase subunit YgfKQuickGO ontologyBLASTP