Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2930244 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
293024429319471704hypothetical proteinBLASTP
293197229338731902group 2 family glycosyl transferase proteinQuickGO ontologyBLASTP
29340972934918822flagellinQuickGO ontologyBLASTP
29351342935961828flagellinQuickGO ontologyBLASTP
29361122936453342hypothetical proteinBLASTP
293648029389152436flagellar hook-associated protein 2QuickGO ontologyBLASTP
29389782939358381flagellar protein FliSQuickGO ontologyBLASTP
29393952939694300hypothetical proteinBLASTP
29397492940105357flaG family proteinQuickGO ontologyBLASTP
29401212940339219carbon storage regulatorQuickGO ontologyBLASTP
29403392940770432flagellar assembly protein FliWQuickGO ontologyBLASTP
29408372941799963flagellar hook-associated protein 3QuickGO ontologyBLASTP
294181729436851869flagellar hook-associated protein FlgKQuickGO ontologyBLASTP
29439742944378405flgN family proteinQuickGO ontologyBLASTP
29443782944659282regulator of flagellin synthesis FlgMQuickGO ontologyBLASTP
294515629463161161flagellar motor switch proteinQuickGO ontologyBLASTP
29463092947304996flagellar motor switch protein FliMQuickGO ontologyBLASTP
29473322947727396putative chemotaxis protein CheWQuickGO ontologyBLASTP
29478272948186360chemotaxis protein CheYQuickGO ontologyBLASTP
29482142948813600chemotaxis protein CheCQuickGO ontologyBLASTP
294883929509142076chemotaxis protein CheAQuickGO ontologyBLASTP
29509272951697771chemotaxis protein methyltransferase CheRQuickGO ontologyBLASTP
295171229527761065protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
29527992953287489chemoreceptor glutamine deamidase CheDQuickGO ontologyBLASTP
29533042953750447chemotaxis protein CheWQuickGO ontologyBLASTP