Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2641446 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
264144626450273582chromosome segregation protein SMCQuickGO ontologyBLASTP
264528926463801092radical SAM domain-containing proteinQuickGO ontologyBLASTP
26463732647077705ribonuclease IIIQuickGO ontologyBLASTP
26472032647436234acyl carrier proteinQuickGO ontologyBLASTP
264751426485211008putative glycerol-3-phosphate acyltransferase PlsXQuickGO ontologyBLASTP
2648611264879318350S ribosomal protein L32QuickGO ontologyBLASTP
26488072649307501ribosomal protein L32 family proteinQuickGO ontologyBLASTP
264942426506171194acetate kinaseQuickGO ontologyBLASTP
26507562651754999phosphotransacetylaseQuickGO ontologyBLASTP
26520882652966879hypothetical proteinBLASTP
26531892653311123hypothetical protein
26533332653578246PrdB proteinQuickGO ontologyBLASTP
26536062654052447putative D-proline reductase PrdB subunitQuickGO ontologyBLASTP
26540822654357276hypothetical proteinBLASTP
265436626564802115D-proline reductase PrdA proproteinQuickGO ontologyBLASTP
26587132659609897hypothetical proteinBLASTP
26600182660149132hypothetical protein
266044126615261086hypothetical proteinBLASTP
266159526626711077hypothetical proteinBLASTP
266321526646601446amino acid permease family proteinQuickGO ontologyBLASTP
26648122665681870hypothetical proteinBLASTP
266620126672081008proline racemaseQuickGO ontologyBLASTP
26684272668546120hypothetical protein
26696252669900276hypothetical proteinBLASTP
266990926720202112D-proline reductase PrdA proproteinQuickGO ontologyBLASTP
26739942674656663hypothetical proteinBLASTP
267469626760001305putative electron transport proteinQuickGO ontologyBLASTP
26759992676115117hypothetical proteinBLASTP
26765932677120528hypothetical proteinBLASTP
26771252677604480hypothetical proteinBLASTP
26777082678007300hypothetical proteinBLASTP
26780832678511429PrdA domain-containing proteinQuickGO ontologyBLASTP
267854226798521311putative electron transport proteinQuickGO ontologyBLASTP
268002726817811755sensory box sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
268212126833501230hypothetical proteinBLASTP