Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2584355 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
258435525855481194aspartate aminotransferaseQuickGO ontologyBLASTP
25862372586593357multidrug resistance protein SMR familyQuickGO ontologyBLASTP
258659025878761287hypothetical proteinBLASTP
25878952588761867phosphoribose diphosphatedecaprenyl-phosphate phosphoribosyltransferaseQuickGO ontologyBLASTP
25889242589184261stage V sporulation protein SQuickGO ontologyBLASTP
258932325908641542phosphodiesteraseQuickGO ontologyBLASTP
259109925921661068recombinase AQuickGO ontologyBLASTP
25923052592889585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
259287325942101338MiaB family RNA modification proteinQuickGO ontologyBLASTP
259433225965812250DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
25968072597487681Clp protease family proteinQuickGO ontologyBLASTP
259772625989311206aspartate kinase IQuickGO ontologyBLASTP
25989472599219273PRC-barrel domain-containing proteinQuickGO ontologyBLASTP
259929626005971302peptidase M16 familyQuickGO ontologyBLASTP
260077226028802109polynucleotide phosphorylasepolyadenylaseQuickGO ontologyBLASTP
2603144260345831530S ribosomal protein S15QuickGO ontologyBLASTP
26035402604460921bifunctional riboflavin kinaseFMN adenylyltransferaseQuickGO ontologyBLASTP
26044732605342870tRNA pseudouridine synthase BQuickGO ontologyBLASTP
26053432606305963DHH family proteinQuickGO ontologyBLASTP
26062952606657363ribosome-binding factor AQuickGO ontologyBLASTP
260668826087542067translation initiation factor IF-2QuickGO ontologyBLASTP
26087722609089318ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
26090762609348273hypothetical proteinBLASTP
260939726107161320transcription elongation factor NusAQuickGO ontologyBLASTP
26107332611194462hypothetical proteinBLASTP
261149926157974299DNA polymerase III PolCQuickGO ontologyBLASTP
2616075261712410504-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseQuickGO ontologyBLASTP
261726126182711011RIP metalloprotease RsePQuickGO ontologyBLASTP
2618316261947311581-deoxy-D-xylulose 5-phosphate reductoisomeraseQuickGO ontologyBLASTP
26195032620483981hypothetical proteinBLASTP
26205832620987405hypothetical proteinBLASTP
26211302621927798phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP