Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2498087 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
249693124980941164hypothetical protein
249808724992441158DNA uptake proteinQuickGO ontologyBLASTP
24993632500208846N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
25002482500442195hypothetical proteinBLASTP
25004592500713255hypothetical proteinBLASTP
25007612501108348hypothetical protein
25012822501428147hypothetical protein
25014312501766336hypothetical protein
250177125036421872hypothetical proteinBLASTP
250364225047361095phage-like proteinQuickGO ontologyBLASTP
25047402505606867phage-like proteinQuickGO ontologyBLASTP
250562025115085889phage tail tape measure protein family core regionQuickGO ontologyBLASTP
251157125126351065putative N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
25126982512874177hypothetical protein
25128672513283417hypothetical proteinBLASTP
25133402513966627hypothetical proteinBLASTP
25139662514304339hypothetical proteinBLASTP
25143042514678375hypothetical proteinBLASTP
25146712515039369hypothetical protein
25150362515344309hypothetical proteinBLASTP
25153472515550204hypothetical proteinBLASTP
251560925166611053hypothetical proteinBLASTP
25166752517067393hypothetical proteinBLASTP
25170882517702615phage scaffold proteinQuickGO ontologyBLASTP
25178532517999147hypothetical protein