Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2393427 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
239342723947701344xanthineuracil permease family proteinQuickGO ontologyBLASTP
23952082396107900hypothetical proteinBLASTP
239644723977661320amino acid permease family proteinQuickGO ontologyBLASTP
23980472398820774putative CoA-substrate-specific enzyme activaseQuickGO ontologyBLASTP
239889724001381242hypothetical proteinBLASTP
240043924014881050electron transfer flavoprotein subunit alphaFixB family proteinQuickGO ontologyBLASTP
24015072402292786electron transfer flavoprotein subunit betaFixA family proteinQuickGO ontologyBLASTP
240233224034651134acyl-CoA dehydrogenase family proteinQuickGO ontologyBLASTP
240372724048541128putative R-2-hydroxyglutaryl-CoA dehydratase subunit betaQuickGO ontologyBLASTP
240485424060861233putative R-2-hydroxyglutaryl-CoA dehydratase subunit alphaQuickGO ontologyBLASTP
240614924073631215CoA-transferase family IIIQuickGO ontologyBLASTP
24081042408925822iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
2409477241074812722-hydroxyglutaryl-CoA dehydratase subunit DQuickGO ontologyBLASTP
241075124124421692putative CoA-substrate-specific enzyme activaseQuickGO ontologyBLASTP
241274124138921152putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
24144762415075600hypothetical proteinBLASTP
24154922416085594GNAT family acetyltransferaseQuickGO ontologyBLASTP