Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2138791 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21387912139417627NADPH-dependent FMN reductaseQuickGO ontologyBLASTP
21403682141366999leucine-rich repeat-containing proteinQuickGO ontologyBLASTP
214138821434752088carbohydrate binding proteinQuickGO ontologyBLASTP
214363721456942058sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
21459472146201255hypothetical proteinBLASTP
21462142146582369putative endoribonuclease L-PSPQuickGO ontologyBLASTP
21466232146877255hypothetical proteinBLASTP
214692221482171296sodiumdicarboxylate symporter family proteinQuickGO ontologyBLASTP
214823921494081170class III aminotransferaseQuickGO ontologyBLASTP
214972321510121290hypothetical proteinBLASTP
21513562152342987leucine-rich repeat-containing proteinQuickGO ontologyBLASTP
215236321545822220hypothetical proteinBLASTP
215481321562521440sensor histidine kinaseQuickGO ontologyBLASTP
21562422156907666DNA-binding response regulatorQuickGO ontologyBLASTP
21573802158195816hypothetical proteinBLASTP
21582212158976756putative ABC transporter permeaseQuickGO ontologyBLASTP
215899221604251434ABC transporter ATP-binding proteinQuickGO ontologyBLASTP