Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:1658505 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
165850516605772073methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
16606121660734123hypothetical protein
16613891661790402hypothetical proteinBLASTP
166199116634901500chitinase AQuickGO ontologyBLASTP
16634951663644150hypothetical protein
16639271664469543hypothetical proteinBLASTP
16646171664970354putative transcriptional regulatorQuickGO ontologyBLASTP
16653731665738366glyoxalase family proteinQuickGO ontologyBLASTP
16657671666237471methylated-DNA--protein-cysteine methyltransferaseQuickGO ontologyBLASTP
166626416674811218AraC family transcriptional regulatorQuickGO ontologyBLASTP
166764616688541209hypothetical proteinBLASTP
16688791669709831hypothetical proteinBLASTP
167022216713341113putative DNA-binding proteinQuickGO ontologyBLASTP
16715481672417870cation efflux family proteinQuickGO ontologyBLASTP
167289416742971404amino acidpeptide transporterQuickGO ontologyBLASTP
16747341675096363putative iron-dependent repressorQuickGO ontologyBLASTP
16751011675487387hypothetical protein
16756131676584972AraC family transcriptional regulatorQuickGO ontologyBLASTP
167682016785651746ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
167857816803111734putative multidrug export ATP-bindingpermeaseQuickGO ontologyBLASTP
16805661680958393hypothetical proteinBLASTP
16810571682007951HDIG domain-containing proteinQuickGO ontologyBLASTP
16820361682272237serthr protein phosphatase family proteinQuickGO ontology