Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:1617902 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16179021618573672putative molybdate ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
16186271619196570hypothetical protein
16195441620464921patatin-like phospholipase family proteinQuickGO ontologyBLASTP
16208141620969156hypothetical proteinBLASTP
162124216222941053uroporphyrinogen decarboxylase family proteinQuickGO ontologyBLASTP
162234216237391398NaH antiporter family proteinQuickGO ontologyBLASTP
162388116256111731iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
16256991626628930CobWP47K family proteinQuickGO ontologyBLASTP
16266521627524873methyltransferase family proteinQuickGO ontologyBLASTP
16275501628212663dimethylamine corrinoid proteinQuickGO ontologyBLASTP
162829216293141023methylcobalamincoenzyme M methyltransferaseQuickGO ontologyBLASTP
162992916309991071uroporphyrinogen decarboxylase family proteinQuickGO ontologyBLASTP
16310221631984963methionine ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
16319861632642657methionine ABC transporter permeaseQuickGO ontologyBLASTP
16328121633630819NLPA family lipoproteinQuickGO ontologyBLASTP
16338411634410570MORN repeat-containing proteinQuickGO ontologyBLASTP
163498816360071020FADFMN-binding family oxidoreductaseQuickGO ontologyBLASTP
163633716373591023asparagine synthetase AsnAQuickGO ontologyBLASTP
163746516390301566FAD-dependent family oxidoreductaseQuickGO ontologyBLASTP
163939016412491860DNA topoisomeraseQuickGO ontologyBLASTP