Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:1581486 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15806691581505837nicotinate-nucleotide diphosphorylaseQuickGO ontologyBLASTP
158148615827871302L-aspartate oxidaseQuickGO ontologyBLASTP
15827901583704915quinolinate synthetaseQuickGO ontologyBLASTP
15840741585000927hypothetical proteinBLASTP
15850971585735639hemolysin IIIQuickGO ontologyBLASTP
158585615869531098GTP-dependent nucleic acid-binding protein EngDQuickGO ontologyBLASTP
15876461588116471cell division protein MraZQuickGO ontologyBLASTP
15881961589125930S-adenosyl-methyltransferase MraWQuickGO ontologyBLASTP
15892071589710504putative cell division protein FtsLQuickGO ontologyBLASTP
158972615919062181stage V sporulation protein DQuickGO ontologyBLASTP
159213615935871452UDP-N-acetylmuramoylalanyl-D-glutamate--2 6-diaminopimelate ligaseQuickGO ontologyBLASTP
159361315950011389UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligaseQuickGO ontologyBLASTP
15950371595990954phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
159606915971811113FtsWRodASpoVE family cell cycle proteinQuickGO ontologyBLASTP
15975001598270771cell division protein FtsQQuickGO ontologyBLASTP
15982811598994714hypothetical proteinBLASTP
15990281599378351small basic proteinQuickGO ontologyBLASTP
15993791600110732hypothetical proteinBLASTP
16002031600874672hypothetical proteinBLASTP
16008951601347453hypothetical proteinBLASTP
16013641601639276YGGT family proteinQuickGO ontologyBLASTP
16016401602410771hypothetical proteinBLASTP
16024261603085660putative septum site-determining protein divIVAQuickGO ontologyBLASTP
1603493160458110893-dehydroquinate synthaseQuickGO ontologyBLASTP