Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:125500 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1258741289903117isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP
129141130139999LacI family transcriptional regulatorQuickGO ontologyBLASTP
1303561344084053hypothetical proteinBLASTP
1344831355501068putative mannose-1-phosphate guanylyltransferasemannose-6-phosphate isomeraseQuickGO ontologyBLASTP
1358861371391254hypothetical proteinBLASTP
137144137950807hypothetical proteinBLASTP
137970138716747hypothetical proteinBLASTP
1389411403231383radical SAM domain-containing proteinQuickGO ontologyBLASTP
1405101417841275putative arabinose-binding proteinQuickGO ontologyBLASTP
1418851430001116putative mannosyltransferaseQuickGO ontologyBLASTP
1431641441741011putative spore coat proteinQuickGO ontologyBLASTP
144189144383195hypothetical protein
144410145177768hypothetical proteinBLASTP
1451901462031014putative spore coat proteinQuickGO ontologyBLASTP
1463781475051128group 1 glycosyl transferase family proteinQuickGO ontologyBLASTP