Pre_GI Gene

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Host: NC_012656 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012656:67949 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
67949691301182surface layer proteinQuickGO ontologyBLASTP
69285716362352S-layer domain proteinQuickGO ontologyBLASTP
7176871929162hypothetical proteinBLASTP
7211272297186hypothetical proteinBLASTP
7354874366819SAF domain family proteinQuickGO ontologyBLASTP
74383758161434type IIIV secretion system proteinQuickGO ontologyBLASTP
7580976741933hypothetical proteinBLASTP
7765377856204hypothetical proteinBLASTP
7792978135207hypothetical proteinBLASTP
7820478812609hypothetical proteinBLASTP
78844799681125pXO1-66QuickGO ontologyBLASTP
8196782512546pXO1-68QuickGO ontologyBLASTP
8321483342129hypothetical protein
8451484630117hypothetical protein
84613859261314pXO1-70QuickGO ontologyBLASTP
8606486960897hypothetical proteinBLASTP
8704687315270pXO1-73QuickGO ontologyBLASTP
8757387758186hypothetical proteinBLASTP
8774888089342hypothetical proteinBLASTP
8808888294207pXO1-74QuickGO ontologyBLASTP
8836188711351pXO1-75QuickGO ontologyBLASTP
8871289626915pXO1-76QuickGO ontologyBLASTP
9799398574582hypothetical proteinBLASTP