Pre_GI Gene

Some Help

Host: NC_012656 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012656:1 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
246674429hypothetical proteinBLASTP
9281071144hypothetical proteinBLASTP
12601373114hypothetical proteinBLASTP
13912029639hypothetical proteinBLASTP
20462279234hypothetical proteinBLASTP
25553139585hypothetical proteinBLASTP
31233737615hypothetical proteinBLASTP
37884423636hypothetical proteinBLASTP
44235052630hypothetical proteinBLASTP
53886101714hypothetical proteinBLASTP
61186696579hypothetical proteinBLASTP
694287501809reverse transcriptaseendonuclease proteinQuickGO ontologyBLASTP
9354119392586hypothetical proteinBLASTP
1201112238228hypothetical proteinBLASTP
12254133451092hypothetical proteinBLASTP
1344813591144hypothetical proteinBLASTP
1360714020414hypothetical proteinBLASTP
1462315327705hypothetical proteinBLASTP
15438194003963hypothetical proteinBLASTP
19464211581695hypothetical proteinBLASTP
2131721430114hypothetical proteinBLASTP
2154321977435hypothetical proteinBLASTP