Pre_GI Gene

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Host: NC_012654 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012654:18893 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1889319051159hypothetical proteinBLASTP
1926720223957LycAQuickGO ontologyBLASTP
2042920914486AraC family transcriptional regulatorQuickGO ontologyBLASTP
2091121279369AraC family transcriptional regulatorQuickGO ontologyBLASTP
2131921438120hypothetical protein
2167022158489hypothetical proteinBLASTP
22234233881155methionine adenosyltransferaseQuickGO ontologyBLASTP
23385256252241chaperone ClpBQuickGO ontologyBLASTP
25622270071386mate efflux family proteinQuickGO ontologyBLASTP
2704127934894hypothetical proteinBLASTP
2795428751798hypothetical proteinBLASTP
2877129256486putative cytidine deoxyribosyltransferaseQuickGO ontologyBLASTP
29282302891008putative thiamine biosynthesis protein ThiHQuickGO ontologyBLASTP
3030230499198hypothetical protein
3056031339780putative menaquinone biosynthesis methlytransferase relatedQuickGO ontology
31353327381386HemN C- region familyQuickGO ontologyBLASTP
32741340061266phenylacetate--CoA ligaseQuickGO ontologyBLASTP
3404834794747creatininaseQuickGO ontologyBLASTP
3481735713897putative hihydroorotate dehydrogenaseQuickGO ontologyBLASTP
3572636208483hypothetical protein
36231372921062putative radical SAM domain proteinQuickGO ontologyBLASTP
3739237532141seroreactive antigen BMN1-5QuickGO ontology
3815838808651putative response regulatorQuickGO ontologyBLASTP
3930640031726hypothetical proteinBLASTP
40259415031245transposase familyQuickGO ontologyBLASTP
4165341820168hypothetical proteinBLASTP
4184542534690hypothetical proteinBLASTP
4268843308621ssDNA-binding proteinQuickGO ontologyBLASTP
43412445571146DNA polymerase III beta subunitQuickGO ontologyBLASTP