Pre_GI Gene

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Host: NC_012654 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012654:170956 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
170956171129174hypothetical protein
1711501722291080hypothetical protein
172249173145897hypothetical protein
1731691745751407putative type II secretion system protein EQuickGO ontologyBLASTP
174605175333729hypothetical protein
1755341799404407hypothetical proteinBLASTP
1801841815121329replicative DNA helicaseQuickGO ontologyBLASTP
181502182320819hypothetical proteinBLASTP
1823071834971191putative viral A-type inclusion protein repeat containing proteinQuickGO ontologyBLASTP
183539183955417hypothetical protein
183948184463516putative sigma KQuickGO ontology
184629185513885putative RNA polymerase sigma factorQuickGO ontologyBLASTP
185604186392789ribosomal protein S1QuickGO ontologyBLASTP
186685186972288LysM domain proteinQuickGO ontology
187310187483174hypothetical proteinBLASTP
1875941895401947ATPase involved in conjugal plasmid transferQuickGO ontologyBLASTP
189540190436897hypothetical protein