Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:897957 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
897957898091135hypothetical proteinBLASTP
8981718993071137spore germination proteinQuickGO ontologyBLASTP
8993089004051098spore germination proteinQuickGO ontologyBLASTP
9004029019401539spore germination proteinQuickGO ontologyBLASTP
9022389051772940molybdopterin oxidoreductase family proteinQuickGO ontologyBLASTP
905190905672483hypothetical proteinBLASTP
905788906132345hypothetical proteinBLASTP
906149906946798formate dehydrogenase accessory proteinQuickGO ontologyBLASTP
9069679079831017molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
908173908952780putative formate transporterQuickGO ontologyBLASTP
9089779099931017thiaminemolybdopterin biosynthesis MoeB-like proteinQuickGO ontologyBLASTP
9100129113191308molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
911300911764465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
911769912005237molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
9120729131211050mrp proteinQuickGO ontologyBLASTP
913137913361225hypothetical proteinBLASTP
913404913802399hypothetical proteinBLASTP
913971914219249hypothetical proteinBLASTP
914310915251942rarD proteinQuickGO ontologyBLASTP
915331915756426hypothetical proteinBLASTP
9158569177091854putative squalene-hopene cyclaseQuickGO ontologyBLASTP
917781917936156hypothetical proteinBLASTP
9180639188037413-ketoacyl-ACP reductaseQuickGO ontologyBLASTP
9188549203381485aldehyde dehydrogenaseQuickGO ontologyBLASTP