Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:803456 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
803456804139684permeaseQuickGO ontologyBLASTP
804127804261135hypothetical proteinBLASTP
804577804777201hypothetical proteinBLASTP
804919805332414mutTnudix family proteinQuickGO ontologyBLASTP
805345806022678hypothetical proteinBLASTP
806019806384366holin-like proteinQuickGO ontologyBLASTP
806537807442906putative als operon regulatory protein AlsRQuickGO ontologyBLASTP
807673808248576hypothetical proteinBLASTP
808453809160708cytochrome c-type biogenesis protein CcdAQuickGO ontologyBLASTP
809251809757507ccdC proteinQuickGO ontologyBLASTP
8098208161616342hypothetical proteinBLASTP
816190816318129hypothetical protein
816439816567129hypothetical proteinBLASTP
816775817092318hypothetical proteinBLASTP
817154817381228hypothetical proteinBLASTP
8176598187291071hypothetical proteinBLASTP
818759819199441hypothetical proteinBLASTP
819303819599297hypothetical proteinBLASTP
819854820384531hypothetical proteinBLASTP
820381820953573thiJpfpI family proteinQuickGO ontologyBLASTP
820967821914948hypothetical proteinBLASTP
822108822548441anti-terminator HutPQuickGO ontologyBLASTP
8226538241701518histidine ammonia-lyaseQuickGO ontologyBLASTP
8241948258521659urocanate hydrataseQuickGO ontologyBLASTP
8258658271361272imidazolonepropionaseQuickGO ontologyBLASTP
827115828086972formimidoylglutamaseQuickGO ontologyBLASTP