Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:755982 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
755982756407426hypothetical proteinBLASTP
756494756916423hypothetical proteinBLASTP
756883757002120hypothetical protein
757672757818147hypothetical protein
757846757983138hypothetical protein
758142758513372hypothetical proteinBLASTP
7585287601981671putative prophage LambdaBa01 terminase large subunitQuickGO ontologyBLASTP
7602147614251212hypothetical proteinBLASTP
761391761975585putative prophage LambdaBa01 prohead proteaseQuickGO ontologyBLASTP
7619897631521164putative phage major capsid proteinQuickGO ontologyBLASTP
763189763479291hypothetical proteinBLASTP
763482763754273hypothetical proteinBLASTP
763751764050300hypothetical proteinBLASTP
764043764399357hypothetical proteinBLASTP
764396764725330hypothetical proteinBLASTP
764726765319594putative prophage LambdaBa01 major tail proteinQuickGO ontologyBLASTP
765324765695372hypothetical proteinBLASTP
765739765900162hypothetical proteinBLASTP
7659167671631248hypothetical proteinBLASTP
7674297698132385putative prophage LambdaBa01 membrane proteinQuickGO ontologyBLASTP
769855770364510phage putative tail component N- domain proteinQuickGO ontologyBLASTP
770427771335909hypothetical proteinBLASTP
7713327739832652phage minor structural proteinQuickGO ontologyBLASTP
7741767760651890prophage LambdaBa01 minor structural proteinQuickGO ontologyBLASTP
776083776358276prophage LambdaBa01 transcriptional regulator AbrB familyQuickGO ontologyBLASTP
776470776895426putative prophage LambdaBa01 holinQuickGO ontologyBLASTP
776895777827933prophage LambdaBa01 N-acetylmuramoyl-L-alanine amidase family 2QuickGO ontologyBLASTP
777942778112171hypothetical proteinBLASTP