Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:639329 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6393296406031275hypothetical proteinBLASTP
6406046418901287zinc protease insulinase familyQuickGO ontologyBLASTP
6419946427077143-ketoacyl-ACP reductaseQuickGO ontologyBLASTP
642783643031249hypothetical proteinBLASTP
643171643956786ACT domain-containing proteinQuickGO ontologyBLASTP
643978644889912hypothetical proteinBLASTP
644953645531579CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
6455526467901239competence damage-inducible protein AQuickGO ontologyBLASTP
646935647561627recombinase AQuickGO ontologyBLASTP
647868648293426recombinase AQuickGO ontologyBLASTP
6487766503381563phosphodiesteraseQuickGO ontologyBLASTP
650504651298795phosphoesterase family proteinQuickGO ontologyBLASTP
651448651708261stage V sporulation protein SQuickGO ontologyBLASTP
651768652691924dipeptidaseQuickGO ontologyBLASTP
6529196546761758putative pyruvate ferredoxin oxidoreductase alpha subunitQuickGO ontologyBLASTP
6546636555298672-oxoglutarate ferredoxin oxidoreductase subunit betaQuickGO ontologyBLASTP
6559576574861530dimethylallyladenosine tRNA methylthiotransferaseQuickGO ontologyBLASTP