Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:519969 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
519969520439471ylmF proteinQuickGO ontologyBLASTP
520446520709264ylmG proteinQuickGO ontologyBLASTP
520725521492768S4 domain-containing proteinQuickGO ontologyBLASTP
521582522088507cell-division initiation protein DivIVAQuickGO ontologyBLASTP
5224365252012766isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP
525357525686330hypothetical proteinBLASTP
525811526269459lipoprotein signal peptidaseQuickGO ontologyBLASTP
526274526540267ribosomal large subunit pseudouridine synthase RluA familyQuickGO ontologyBLASTP
526537527256720ribosomal large subunit pseudouridine synthase RluA familyQuickGO ontologyBLASTP
527459528001543bifunctional pyrimidine regulatory protein PyrRuracil phosphoribosyltransferaseQuickGO ontologyBLASTP
5281485294311284uracil permeaseQuickGO ontologyBLASTP
529580530494915aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
5304785317641287dihydroorotaseQuickGO ontologyBLASTP
5317615328581098carbamoyl phosphate synthase small subunitQuickGO ontologyBLASTP
5328435360613219carbamoyl phosphate synthase large subunitQuickGO ontologyBLASTP
536058536837780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
536834537763930dihydroorotate dehydrogenase 1BQuickGO ontologyBLASTP
537748538464717orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
538461539093633orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
539501539812312haloacid dehalogenase-like family hydrolaseQuickGO ontologyBLASTP
539882540088207hypothetical proteinBLASTP