Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:5085915 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
50853165085918603DNA-binding response regulatorQuickGO ontologyBLASTP
508591550870451131sensor histidine kinaseQuickGO ontologyBLASTP
50870465087780735ABC transporter permeaseQuickGO ontologyBLASTP
50877775088679903ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
50888855089631747methionine aminopeptidaseQuickGO ontologyBLASTP
509045850922931836collagen adhesion proteinQuickGO ontologyBLASTP
509232850955043177collagen adhesion proteinQuickGO ontologyBLASTP
509560850980822475LPXTG-motif cell wall anchor domain-containing proteinQuickGO ontologyBLASTP
50983395098470132hypothetical proteinBLASTP
509857050999701401putative aminopeptidaseQuickGO ontologyBLASTP
51001195100493375hypothetical proteinBLASTP
51005195101190672hypothetical proteinBLASTP
51011745101488315hypothetical proteinBLASTP
51014755102002528RNA polymerase sigma factorQuickGO ontologyBLASTP
510239951040691671arginyl-tRNA synthetaseQuickGO ontologyBLASTP
51040695104506438hypothetical proteinBLASTP
51047095105695987hypothetical proteinBLASTP
51057215106083363hypothetical proteinBLASTP