Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:5052000 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
50522385052735498putative PTS system glucose-specific IIA componentQuickGO ontologyBLASTP
50531225053508387hypothetical proteinBLASTP
50536685054279612hypothetical proteinBLASTP
50544725054750279hypothetical proteinBLASTP
50549815055529549hypothetical proteinBLASTP
505560750566471041sua5yciOyrdCywlC family proteinQuickGO ontologyBLASTP
50567565057214459hypothetical proteinBLASTP
50572645058139876putative stage II sporulation protein RQuickGO ontologyBLASTP
50582435059094852protein-glutamine-N5 methyltransferaseQuickGO ontologyBLASTP
505909450601701077peptide chain release factor 1QuickGO ontologyBLASTP
50604325061016585thymidine kinaseQuickGO ontologyBLASTP
5061125506137024650S ribosomal protein L31QuickGO ontologyBLASTP
506177450630451272transcription termination factor RhoQuickGO ontologyBLASTP
50633885064353966fructose 16-bisphosphatase IIQuickGO ontologyBLASTP
506447150657601290UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50660925066949858fructose-bisphosphate aldolaseQuickGO ontologyBLASTP
50671605067528369sporulation initiation phosphotransferase FQuickGO ontologyBLASTP
50677305068254525hypothetical proteinBLASTP
506828650698931608CTP synthetaseQuickGO ontologyBLASTP
50701515070678528DNA-directed RNA polymerase subunit deltaQuickGO ontologyBLASTP
50708335071462630TetR family transcriptional regulatorQuickGO ontologyBLASTP
507152750726661140acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507268850738181131acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507389250747438523-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP