Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:5008749 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
500874950113162568hypothetical proteinBLASTP
50113135011576264hypothetical proteinBLASTP
501182950131271299glycoside hydrolase family proteinQuickGO ontologyBLASTP
501307850143191242glycoside hydrolase family proteinQuickGO ontologyBLASTP
501461350156141002rod shape-determining protein MblQuickGO ontologyBLASTP
50157765015982207stage III sporulation protein DQuickGO ontologyBLASTP
50164535016833381putative lipoproteinQuickGO ontologyBLASTP
50169895017123135hypothetical proteinBLASTP
50172655018170906stage II sporulation proteinQuickGO ontologyBLASTP
50183325019036705ABC transporter permeaseQuickGO ontologyBLASTP
50190365019878843ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
50200605020473414putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
50205585021067510ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
502119550222141020stage II sporulation protein DQuickGO ontologyBLASTP
502242250237261305UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50237665024470705hypothetical proteinBLASTP
50245225024758237hypothetical proteinBLASTP
502512450266441521NADH dehydrogenase subunit NQuickGO ontologyBLASTP
502664650281391494NADH dehydrogenase subunit MQuickGO ontologyBLASTP
502813650299981863NADH dehydrogenase subunit LQuickGO ontologyBLASTP
50300285030342315NADH dehydrogenase subunit KQuickGO ontologyBLASTP
50303355030859525NADH dehydrogenase subunit JQuickGO ontologyBLASTP
50308565031275420NADH dehydrogenase subunit IQuickGO ontologyBLASTP
503130150323021002NADH dehydrogenase subunit HQuickGO ontologyBLASTP
503230250334021101NADH dehydrogenase subunit DQuickGO ontologyBLASTP