Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:4882525 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48825254883037513transferaseQuickGO ontologyBLASTP
48830614883711651pyrophosphatase PpaXQuickGO ontologyBLASTP
48837794884591813prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
48846164885545930HPr kinasephosphorylaseQuickGO ontologyBLASTP
48857024886082381hypothetical proteinBLASTP
48861974886646450hypothetical proteinBLASTP
488670648895822877excinuclease ABC subunit AQuickGO ontologyBLASTP
488958848915641977excinuclease ABC subunit BQuickGO ontologyBLASTP
489172548927651041transposase IS605 familyQuickGO ontologyBLASTP
48933004893683384putative lipoproteinQuickGO ontologyBLASTP
48937774894397621hypothetical proteinBLASTP
48943944895155762MerR family transcriptional regulatorQuickGO ontologyBLASTP
48952554895386132hypothetical proteinBLASTP
48954994895891393hypothetical proteinBLASTP
48958884896109222hypothetical proteinBLASTP
48961224896319198DNA-binding proteinQuickGO ontologyBLASTP
489665448976761023hypothetical proteinBLASTP
48978274898720894LysR family transcriptional regulatorQuickGO ontologyBLASTP
48987724899137366MerR family transcriptional regulatorQuickGO ontologyBLASTP
48991424899687546FMN reductase NADPH-dependentQuickGO ontologyBLASTP
489995349015871635putative macrolide efflux pumpQuickGO ontologyBLASTP
49017464902003258hypothetical proteinBLASTP
490206849037831716ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
490409549052791185hypothetical proteinBLASTP
490538949068251437carboxyl-terminal proteaseQuickGO ontologyBLASTP
49069444907837894ABC transporter permeaseQuickGO ontologyBLASTP
49078274908471645ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
49088004909123324cytochrome c-551QuickGO ontologyBLASTP
491080349133102508preprotein translocase subunit SecAQuickGO ontologyBLASTP
49135874914129543ribosomal subunit interface proteinQuickGO ontologyBLASTP
49141544914288135hypothetical proteinBLASTP
49144534914650198cold shock protein CspCQuickGO ontologyBLASTP
49147774915349573comF operon protein 3QuickGO ontologyBLASTP
491548149168301350comF operon protein 1QuickGO ontologyBLASTP
491695849182681311putative cell wall endopeptidase NlpCP60 familyQuickGO ontologyBLASTP
49185214918835315hypothetical proteinBLASTP
49190094919851843degV family proteinQuickGO ontologyBLASTP
49200914920726636hypothetical proteinBLASTP