Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:4856620 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485662048576601041phage major capsid protein HK97 familyQuickGO ontologyBLASTP
48577474858727981hypothetical proteinBLASTP
48587954859661867hypothetical proteinBLASTP
48597844860689906prophage LambdaBa03 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
486083348621281296phosphopyruvate hydrataseQuickGO ontologyBLASTP
486215948636881530phosphoglyceromutaseQuickGO ontologyBLASTP
48636854864440756triosephosphate isomeraseQuickGO ontologyBLASTP
486447348656571185phosphoglycerate kinaseQuickGO ontologyBLASTP
486579748668011005glyceraldehyde-3-phosphate dehydrogenase type IQuickGO ontologyBLASTP
486682848678561029gapA transcriptional regulator CggRQuickGO ontologyBLASTP
48679934868238246glutaredoxin family proteinQuickGO ontologyBLASTP
486824848695551308RNA polymerase factor sigma-54QuickGO ontologyBLASTP
48700954870301207hypothetical proteinBLASTP
48703384870880543putative lipoproteinQuickGO ontologyBLASTP
48709114871387477SpoVA family proteinQuickGO ontologyBLASTP
487138848724041017stage V sporulation protein ADQuickGO ontologyBLASTP
48724014872751351SpoVA family proteinQuickGO ontologyBLASTP
48727634872969207hypothetical proteinBLASTP
48729904873859870hypothetical proteinBLASTP
48741014874682582ATP-dependent Clp protease proteolytic subunitQuickGO ontologyBLASTP
48750064875254249phosphocarrier protein ChrQuickGO ontologyBLASTP