Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:466798 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
466798467013216prophage LambdaBa02 HNH endonuclease family proteinQuickGO ontologyBLASTP
467175467555381hypothetical proteinBLASTP
4675364693081773putative prophage LambdaBa02 terminase large subunitQuickGO ontologyBLASTP
4693694705381170hypothetical proteinBLASTP
470549471271723prophage LambdaBa02 Clp protease family proteinQuickGO ontologyBLASTP
4712684724551188putative prophage LambdaBa02 major capsid proteinQuickGO ontologyBLASTP
472532472732201hypothetical proteinBLASTP
472741473016276hypothetical proteinBLASTP
473018473302285hypothetical proteinBLASTP
473338473775438hypothetical proteinBLASTP
473772474131360hypothetical proteinBLASTP
474145474729585putative prophage LambdaBa02 major tail proteinQuickGO ontologyBLASTP
474789475199411hypothetical proteinBLASTP
475201475341141hypothetical proteinBLASTP
4753574796944338putative prophage LambdaBa02 tape measure proteinQuickGO ontologyBLASTP
479760480371612hypothetical proteinBLASTP
4804084818891482hypothetical proteinBLASTP
4818864838681983phage minor structural proteinQuickGO ontologyBLASTP
4838924859702079hypothetical proteinBLASTP