Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:4509491 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45094914509922432hypothetical proteinBLASTP
45102954510573279hypothetical proteinBLASTP
45106084510790183hypothetical proteinBLASTP
45107924511028237hypothetical proteinBLASTP
45112844511745462CarD family transcriptional regulatorQuickGO ontologyBLASTP
45118054512590786glucose-1-dehydrogenaseQuickGO ontologyBLASTP
45126044513461858glucose uptake proteinQuickGO ontologyBLASTP
45134984513917420hypothetical proteinBLASTP
45140114514244234molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
45142474514711465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
45147084515223516molybdopterin-guanine dinucleotide biosynthesis protein MobBQuickGO ontologyBLASTP
451519345164821290molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
45165664517051486molybdenum cofactor biosynthesis protein MoaCQuickGO ontologyBLASTP
451709045181031014thiaminemolybdopterin biosynthesis MoeB-like proteinQuickGO ontologyBLASTP
45181204518299180molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
45184144519040627molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
451930945216002292collagen triple helix repeat domain proteinQuickGO ontologyBLASTP
45217744522103330hypothetical proteinBLASTP
45221184522342225hypothetical proteinBLASTP
45224204522725306rhodanese-like domain-containing proteinQuickGO ontologyBLASTP
45229264523108183hypothetical proteinBLASTP
452315845242821125homoserine O-acetyltransferaseQuickGO ontologyBLASTP
45244684524902435hypothetical protein
45248654525044180hypothetical proteinBLASTP
452523345266001368spore germination protein gerhaQuickGO ontologyBLASTP
452661845277121095spore germination protein GerHBQuickGO ontologyBLASTP
452768845287671080spore germination protein GerHCQuickGO ontologyBLASTP
45288584529043186hypothetical proteinBLASTP
45292334529655423hypothetical proteinBLASTP
45297004530452753vrrB proteinQuickGO ontologyBLASTP
45305294530681153hypothetical proteinBLASTP
453070945331172409leucyl-tRNA synthetaseQuickGO ontologyBLASTP
453359245347851194putative permeaseQuickGO ontologyBLASTP