Pre_GI Gene

Some Help

Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:4478036 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
447803644790521017putative lipoproteinQuickGO ontologyBLASTP
44791704479496327hypothetical proteinBLASTP
44794964480008513hypothetical proteinBLASTP
448019644813111116putative aminopeptidaseQuickGO ontologyBLASTP
44813524481783432putative lipoproteinQuickGO ontologyBLASTP
44819784482382405hypothetical proteinBLASTP
44824744483028555putative ribosomal-protein-serine acetyltransferaseQuickGO ontologyBLASTP
448322544845351311UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
448478844859061119nicotinate phosphoribosyltransferaseQuickGO ontologyBLASTP
448596844899303963FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
44901524490496345hypothetical proteinBLASTP
44909314491545615putative tRNA binding domain proteinQuickGO ontologyBLASTP
44915424492375834hypothetical proteinBLASTP
44924344492748315thioredoxin family proteinQuickGO ontologyBLASTP
44928324493341510NTPaseQuickGO ontologyBLASTP
449358344946561074peptidase M42 familyQuickGO ontologyBLASTP
44948054495116312hypothetical proteinBLASTP
44953524496206855metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
44962764496929654tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
44971624497440279hypothetical proteinBLASTP
44974444498241798aminoglycoside phosphotransferase family proteinQuickGO ontologyBLASTP
449847145006122142putative pullulanaseQuickGO ontologyBLASTP