Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:4118366 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41178994118369471putative metalloproteaseQuickGO ontologyBLASTP
411836641205102145HDIG domain proteinQuickGO ontologyBLASTP
41207044121663960PhoH family proteinQuickGO ontologyBLASTP
412166741228661200sporulation proteinQuickGO ontologyBLASTP
41230434123336294sporulation protein YqfCQuickGO ontologyBLASTP
41234454123888444gatBYqey domain proteinQuickGO ontologyBLASTP
4123904412407717430S ribosomal protein S21QuickGO ontologyBLASTP
412440841257601353MiaB family RNA modification proteinQuickGO ontologyBLASTP
4125767412651675016S ribosomal RNA methyltransferase RsmEQuickGO ontologyBLASTP
4126662412760093950S ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
412762941287441116chaperone protein DnaJQuickGO ontologyBLASTP
412894941307841836molecular chaperone DnaKQuickGO ontologyBLASTP
41308114131377567heat shock protein GrpEQuickGO ontologyBLASTP
413149241325081017heat-inducible transcription repressorQuickGO ontologyBLASTP
413264241337781137coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
41338344134208375hypothetical proteinBLASTP
413434041361631824GTP-binding protein LepAQuickGO ontologyBLASTP
41363744136736363hypothetical proteinBLASTP
413673641378421107germination proteaseQuickGO ontologyBLASTP