Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:2178000 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21783862178775390hypothetical proteinBLASTP
21788102179442633hypothetical proteinBLASTP
21800022180700699hypothetical proteinBLASTP
21807142180995282hypothetical proteinBLASTP
21812532181717465transposase IS110 family OrfBQuickGO ontologyBLASTP
21817142182487774transposase IS110 family OrfAQuickGO ontologyBLASTP
21826462183428783putative site-specific recombinaseQuickGO ontologyBLASTP
21834132183550138hypothetical proteinBLASTP
21840112184367357hypothetical proteinBLASTP
218439421856291236hypothetical proteinBLASTP
21858662186303438hypothetical proteinBLASTP
218637421877681395group-specific proteinQuickGO ontologyBLASTP
21878582188487630group-specific proteinQuickGO ontologyBLASTP
21885022188975474hypothetical proteinBLASTP
218899921902791281TPR domain-containing proteinQuickGO ontologyBLASTP
219026921916751407hypothetical proteinBLASTP
21917592192031273hypothetical proteinBLASTP
219215921961664008FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
21961982196560363hypothetical protein
21965892197362774hypothetical protein
21973752198139765hypothetical proteinBLASTP
219834021996381299aspartyl-tRNA synthetaseQuickGO ontologyBLASTP
21998582200598741UDP-N-acetylmuramoylalanyl-D-glutamyl-2 6-diaminopimelate--D-alanyl-D-alanyl ligaseQuickGO ontologyBLASTP