Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:1075663 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10756631076457795short chain dehydrogenasereductase family oxidoreductaseQuickGO ontologyBLASTP
107671710777241008oxidoreductase zinc-binding dehydrogenase familyQuickGO ontologyBLASTP
10778301078009180hypothetical protein
10781351079097963luciferase family proteinQuickGO ontologyBLASTP
10791111080064954zinc-containing alcohol dehydrogenaseQuickGO ontologyBLASTP
10801541080702549glucose-6-phosphate dehydrogenaseQuickGO ontologyBLASTP
108105310825371485glucose-6-phosphate 1-dehydrogenaseQuickGO ontologyBLASTP
108257710846012025transketolaseQuickGO ontologyBLASTP
108470610855998946-phosphogluconate dehydrogenaseQuickGO ontologyBLASTP
10856511086319669putative translaldolaseQuickGO ontologyBLASTP
108670910880341326gluconate permeaseQuickGO ontologyBLASTP
108809010896311542gluconate kinaseQuickGO ontologyBLASTP
108975310908201068hypothetical proteinBLASTP
10910001091176177hypothetical proteinBLASTP
10913721092193822pentapeptide repeats domain proteinQuickGO ontologyBLASTP
10922391093123885transporter EamA familyQuickGO ontologyBLASTP
10935981093978381putative transcriptional regulatorQuickGO ontologyBLASTP
109409810954261329hypothetical proteinBLASTP
10954791095892414putative ATP synthase protein IQuickGO ontologyBLASTP
10960921096640549hypothetical proteinBLASTP
10967161096955240hypothetical proteinBLASTP
10970321097427396putative lipoproteinQuickGO ontologyBLASTP
10976951098609915TPR domain-containing proteinQuickGO ontologyBLASTP