Pre_GI Gene

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Host: NC_012579 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012579:72715 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7271573575861Flp pilus assembly protein CpaBQuickGO ontologyBLASTP
7359274410819SAF domain familyQuickGO ontologyBLASTP
74427758601434type IIIV secretion system proteinQuickGO ontologyBLASTP
7585376785933hypothetical proteinBLASTP
7678777497711hypothetical proteinBLASTP
7749977654156hypothetical proteinBLASTP
7769777900204hypothetical proteinBLASTP
7797378179207hypothetical proteinBLASTP
7824878856609hypothetical proteinBLASTP
78927800121086hypothetical proteinBLASTP
80043817911749hypothetical proteinBLASTP
8201182556546hypothetical proteinBLASTP
8263483041408hypothetical proteinBLASTP
8391484378465hypothetical proteinBLASTP
84657859701314hypothetical proteinBLASTP
8610887016909hypothetical proteinBLASTP
8710287371270hypothetical proteinBLASTP
8762987814186hypothetical proteinBLASTP
8780487929126hypothetical proteinBLASTP
8801588350336hypothetical proteinBLASTP
8841788767351hypothetical proteinBLASTP
8876889682915hypothetical proteinBLASTP
89685917842100hypothetical proteinBLASTP
91815954833669hypothetical proteinBLASTP