Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3921859 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39218593922506648haloacid dehalogenase IA family proteinQuickGO ontologyBLASTP
39225303923315786sorbitol-6-phosphate 2-dehydrogenaseQuickGO ontologyBLASTP
39233363923701366PTS system glucitolsorbitol-specific IIA componentQuickGO ontologyBLASTP
392391739249211005PTS system glucitolsorbitol-specific IIBC componentQuickGO ontologyBLASTP
39249343925479546PTS system glucitolsorbitol-specific IIC componentQuickGO ontologyBLASTP
39255223925917396glucitol operon activator proteinQuickGO ontologyBLASTP
392593139269801050putative L-iditol 2-dehydrogenaseQuickGO ontologyBLASTP
39270153927986972putative glucitol operon regulatorQuickGO ontologyBLASTP
392834239296911350phosphoglucosamine mutaseQuickGO ontologyBLASTP
392982639303565312-oxoacidacceptor oxidoreductase gamma subunit pyruvate2-ketoisovalerate familyQuickGO ontologyBLASTP
39303583931107750putative 2-oxoacidacceptor oxidoreductase beta subunitQuickGO ontologyBLASTP
393110739321771071putative 2-oxoacidacceptor oxidoreductase alpha subunitQuickGO ontologyBLASTP
39321933932402210putative 2-oxoacidacceptor oxidoreductase delta subunitQuickGO ontologyBLASTP
39325043933166663hypothetical proteinBLASTP
393342939344991071butyrate kinaseQuickGO ontologyBLASTP
39345283935439912phosphate butyryltransferaseQuickGO ontologyBLASTP
393543239365261095butyrate kinaseQuickGO ontologyBLASTP
393662739382251599oxidoreductase FAD-bindingQuickGO ontologyBLASTP
393822739395071281hypothetical proteinBLASTP
39394773940325849hypothetical protein TIGR00159QuickGO ontologyBLASTP
39405803941113534cell wall hydrolase family proteinQuickGO ontologyBLASTP