Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3556763 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35567633557596834hypothetical proteinBLASTP
35577943558696903phosphate acetylbutyryl transferaseQuickGO ontologyBLASTP
355915935601721014dehydrogenase FMN-dependentQuickGO ontologyBLASTP
35604083560878471hypothetical proteinBLASTP
356106635634322367MutS2 family proteinQuickGO ontologyBLASTP
356356535659312367peptidase U32 familyQuickGO ontologyBLASTP
35665083567380873hypothetical proteinBLASTP
356758535693601776hypothetical proteinBLASTP
35695313569683153hypothetical proteinBLASTP
35698633570129267hypothetical proteinBLASTP
35705033570961459glycosyl transferase group 2 familyQuickGO ontologyBLASTP
35709833571573591hypothetical proteinBLASTP
357177835741592382phenylalanyl-tRNA synthetase beta subunitQuickGO ontologyBLASTP
357432035753391020phenylalanyl-tRNA synthetase alpha subunitQuickGO ontologyBLASTP