Pre_GI Gene

Some Help

Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3416509 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
341650934177831275Spo0B-associated GTP-binding proteinQuickGO ontologyBLASTP
34181623418464303ribosomal protein L27QuickGO ontologyBLASTP
34184673418793327hypothetical proteinBLASTP
34187963419110315ribosomal protein L21QuickGO ontologyBLASTP
341923434206731440ribonuclease RneRng familyQuickGO ontologyBLASTP
34207123421425714hypothetical proteinBLASTP
342140334232531851radical SAM domain proteinQuickGO ontologyBLASTP
34233663424217852putative metalloproteaseQuickGO ontologyBLASTP
34242723425057786peptidase family M23M37QuickGO ontologyBLASTP
342537734264951119rod shape-determining protein RodAQuickGO ontologyBLASTP
34265943426857264cell division topological specificity factor MinEQuickGO ontologyBLASTP
34268713427668798septum site-determining protein MinDQuickGO ontologyBLASTP
34276863428315630septum site-determining protein MinCQuickGO ontologyBLASTP
342849034312642775penicillin-binding proteinQuickGO ontologyBLASTP
34312843431775492rod shape-determining protein MreDQuickGO ontologyBLASTP
34317863432643858rod shape-determining protein MreCQuickGO ontologyBLASTP
343265034336601011rod shape-determining protein MreBQuickGO ontologyBLASTP
34336893434375687DNA repair protein RadC familyQuickGO ontologyBLASTP
34343903434974585septum formation protein MafQuickGO ontologyBLASTP
34349903435247258hypothetical proteinBLASTP