Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3374904 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
33749043375602699diacylglycerol kinasePAP2 family proteinQuickGO ontologyBLASTP
33756433376143501hypothetical protein TIGR00043QuickGO ontologyBLASTP
337614033782272088putative hydrolaseQuickGO ontologyBLASTP
337825033794101161sporulation protein YqfDQuickGO ontologyBLASTP
33794003379696297sporulation protein YqfCQuickGO ontologyBLASTP
33798103380256447GatBYqey domain proteinQuickGO ontologyBLASTP
33802993380475177ribosomal protein S21QuickGO ontologyBLASTP
33806123380956345HIT family proteinQuickGO ontologyBLASTP
338101333823111299RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
33823113383069759hypothetical protein TIGR00046QuickGO ontologyBLASTP
33831673384105939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
338428133854261146chaperone protein DnaJQuickGO ontologyBLASTP
338556933874401872chaperone protein DnaKQuickGO ontologyBLASTP
33874953388139645co-chaperone GrpEQuickGO ontologyBLASTP
338816633891971032heat-inducible transcription repressor HrcAQuickGO ontologyBLASTP
338939833905401143oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
339056733923751809GTP-binding protein LepAQuickGO ontologyBLASTP
33925163392911396hypothetical proteinBLASTP
339298233940731092stage II sporulation proteinQuickGO ontologyBLASTP
33942583395232975spore proteaseQuickGO ontologyBLASTP
33954423395708267ribosomal protein S20QuickGO ontologyBLASTP
339574333967741032DNA polymerase III delta subunitQuickGO ontologyBLASTP
339680333985901788ComECRec2 family proteinQuickGO ontologyBLASTP