Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3288124 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
328812432907692646magnesium-importing ATPaseQuickGO ontologyBLASTP
32916423292046405hypothetical proteinBLASTP
329237332936141242phosphoribosylamine--glycine ligaseQuickGO ontologyBLASTP
329376332952621500phosphoribosylaminoimidazolecarboxamide formyltransferaseIMP cyclohydrolaseQuickGO ontologyBLASTP
32954763296093618phosphoribosylglycinamide formyltransferaseQuickGO ontologyBLASTP
32962203297215996phosphoribosylformylglycinamidine cyclo-ligaseQuickGO ontologyBLASTP
329727632987241449amidophosphoribosyltransferaseQuickGO ontologyBLASTP
32988163299520705phosphoribosylaminoimidazolesuccinocarboxamide synthaseQuickGO ontologyBLASTP
32995203299999480phosphoribosylaminoimidazole carboxylase catalytic subunitQuickGO ontologyBLASTP
330062833031832556xanthine dehydrogenase family protein molybdopterin-binding subunitQuickGO ontologyBLASTP
330355833047751218peptidase M20M25M40 familyQuickGO ontologyBLASTP
330480133061291329amidohydrolase family proteinQuickGO ontologyBLASTP
330616033091773018putative selenate reductase YgfK subunitQuickGO ontologyBLASTP