Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2925472 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
292547229265271056hypothetical proteinBLASTP
29268662927558693hypothetical proteinBLASTP
29281932928426234hypothetical protein
29286142929201588hypothetical proteinBLASTP
29293302930091762bacteriophage endolysinQuickGO ontologyBLASTP
29301332930306174hypothetical proteinBLASTP
29303082930511204bacteriocin UviBQuickGO ontologyBLASTP
29306092930770162hypothetical proteinBLASTP
29307702931066297hypothetical proteinBLASTP
293107829323461269hypothetical proteinBLASTP
293234629335031158hypothetical proteinBLASTP
29335072934376870hypothetical proteinBLASTP
293439229383183927phage tail tape measure protein familyQuickGO ontologyBLASTP
29383752938494120hypothetical proteinBLASTP
29386082939000393hypothetical proteinBLASTP
29390582939639582phage major tail protein Phi13 familyQuickGO ontologyBLASTP
29397032940059357hypothetical proteinBLASTP
29400752940434360phage protein HK97 gp10 familyQuickGO ontologyBLASTP
29404352940803369phage head-tail adaptor proteinQuickGO ontologyBLASTP
29407932941086294hypothetical proteinBLASTP
294117129424031233phage major capsid protein HK97 familyQuickGO ontologyBLASTP
29424772943202726Clp proteaseQuickGO ontologyBLASTP
294319529444451251phage portal protein HK97 familyQuickGO ontologyBLASTP
29444892944671183hypothetical proteinBLASTP
294469529464521758putative phage terminase large subunitQuickGO ontologyBLASTP
29464532946938486phage terminase small subunit P27 familyQuickGO ontologyBLASTP
29470852947552468HNH endonuclease domain proteinQuickGO ontologyBLASTP
294765329494461794hypothetical proteinBLASTP
29496652950258594hypothetical proteinBLASTP
29502802950477198hypothetical proteinBLASTP
29505072950752246hypothetical proteinBLASTP
29508772951059183hypothetical proteinBLASTP
29511282951340213hypothetical proteinBLASTP
29514172951737321hypothetical proteinBLASTP
29517682951962195hypothetical protein
29519632952211249hypothetical proteinBLASTP
29522592952846588GIY-YIG domain proteinQuickGO ontology
29531422953597456hypothetical protein
29536252953921297hypothetical protein
295422129571152895hypothetical proteinBLASTP
29572722957436165hypothetical protein
295779529589311137hypothetical protein
29589772959930954hypothetical protein
29600072960804798hypothetical protein
29608542961012159hypothetical proteinBLASTP
29610762961495420hypothetical protein
29619312962587657DNA-binding proteinQuickGO ontologyBLASTP
29627192962859141hypothetical proteinBLASTP
29628702963199330hypothetical proteinBLASTP
29633862963628243transcription regulator CroCI family -related proteinQuickGO ontologyBLASTP
29638392964048210hypothetical protein