Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2721658 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27216582722620963DHH family proteinQuickGO ontologyBLASTP
27226102722972363ribosome-binding factor AQuickGO ontologyBLASTP
272300327250692067translation initiation factor IF-2QuickGO ontologyBLASTP
27250872725404318rRNA-binding proteinQuickGO ontologyBLASTP
27253912725663273hypothetical proteinBLASTP
272572227270951374N utilization substance protein AQuickGO ontologyBLASTP
27271122727573462hypothetical proteinBLASTP
272787827321764299DNA polymerase III alpha subunit Gram-positive typeQuickGO ontologyBLASTP
2732455273350410504-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseQuickGO ontologyBLASTP
273364527346551011RIP metalloprotease RsePQuickGO ontologyBLASTP
2734700273585711581-deoxy-D-xylulose 5-phosphate reductoisomeraseQuickGO ontologyBLASTP
27358942736874981hypothetical proteinBLASTP
27369742737096123hypothetical proteinBLASTP
27371552737343189hypothetical proteinBLASTP
27375282738325798phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
27383502739108759di-transpoly-cis-decaprenylcistransferaseQuickGO ontologyBLASTP
27391742739728555ribosome recycling factorQuickGO ontologyBLASTP
27397442740460717UMP kinaseQuickGO ontologyBLASTP
27408352741758924translation elongation factor TsQuickGO ontologyBLASTP