Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2597934 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25979342598122189hypothetical protein
25981682598341174hypothetical proteinBLASTP
25983932598611219hypothetical protein
25986352598982348hypothetical proteinBLASTP
25989852599389405hypothetical proteinBLASTP
25993862599550165hypothetical protein
25995402599905366phage proteinQuickGO ontologyBLASTP
25999822600695714hypothetical proteinBLASTP
26007222601114393replication terminator protein phage associatedQuickGO ontologyBLASTP
26012122601592381MazG nucleotide pyrophosphohydrolase domain proteinQuickGO ontologyBLASTP
26015922601831240transcriptional regulator AbrB familyQuickGO ontologyBLASTP
26018342602154321hypothetical proteinBLASTP
26021562603034879phage proteinQuickGO ontologyBLASTP
26030462603285240hypothetical proteinBLASTP
26033022604105804putative DNA replication protein DnaCQuickGO ontologyBLASTP
26040652604937873putative phage replisome organizerQuickGO ontologyBLASTP
26049602605259300hypothetical proteinBLASTP
26053532605529177hypothetical proteinBLASTP
26055452605691147hypothetical proteinBLASTP
26056942606554861hypothetical proteinBLASTP
26065662607051486hypothetical proteinBLASTP
26071832607347165hypothetical proteinBLASTP
26073562607514159hypothetical proteinBLASTP
26075672607719153hypothetical proteinBLASTP
26077402607949210hypothetical proteinBLASTP
26079612608749789phage antirepressor proteinQuickGO ontologyBLASTP
26088032609024222hypothetical proteinBLASTP
26091572609615459immunity repressor proteinQuickGO ontologyBLASTP
26096622610096435hypothetical proteinBLASTP
261023926116001362phage proteinQuickGO ontologyBLASTP
261169526133171623resolvaseQuickGO ontologyBLASTP
26136062614307702oxidoreductase family proteinQuickGO ontologyBLASTP
26144022614569168hypothetical proteinBLASTP
26148702615277408hypothetical proteinBLASTP
26153582615951594putative lipoproteinQuickGO ontologyBLASTP