Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2566500 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25666442567405762N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
25674432567637195hypothetical proteinBLASTP
25676542567908255hypothetical proteinBLASTP
25680152568176162hypothetical proteinBLASTP
25681762568472297hypothetical proteinBLASTP
256848825696541167tail fiber proteinQuickGO ontologyBLASTP
25696572570292636hypothetical proteinBLASTP
257028925714191131putative baseplate J-like proteinQuickGO ontologyBLASTP
25714252571877453hypothetical proteinBLASTP
25718702572202333hypothetical proteinBLASTP
25721862573154969hypothetical proteinBLASTP
25731542573843690hypothetical proteinBLASTP
25738742574386513puattive membrane proteinQuickGO ontologyBLASTP
257444025774182979phage tail tape measure protein TP901 familyQuickGO ontologyBLASTP
25774192577565147hypothetical proteinBLASTP
25776012578035435hypothetical proteinBLASTP
25780592578469411hypothetical proteinBLASTP
257848225798881407putative tail sheath proteinQuickGO ontologyBLASTP
25798882580079192hypothetical proteinBLASTP
25800902580911822hypothetical proteinBLASTP
25809142581321408hypothetical proteinBLASTP
25813232581709387hypothetical proteinBLASTP
25817102582030321hypothetical proteinBLASTP
25820332582224192hypothetical proteinBLASTP
258228125833331053hypothetical proteinBLASTP
25833472583739393hypothetical proteinBLASTP
25837602584374615phage scaffold proteinQuickGO ontologyBLASTP