Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2466000 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24660992466998900hypothetical proteinBLASTP
246733824686601323amino acid permease family proteinQuickGO ontologyBLASTP
24687282469462735protein kinase domain proteinQuickGO ontologyBLASTP
246994924707227742-hydroxyglutaryl-CoA dehydratase component AQuickGO ontologyBLASTP
247079924724991701hypothetical proteinBLASTP
247280024738491050electron transfer flavoprotein alpha subunitFixB family proteinQuickGO ontologyBLASTP
24738682474653786electron transfer flavoprotein beta subunitFixA family proteinQuickGO ontologyBLASTP
247469024758231134acyl-CoA dehydrogenase family proteinQuickGO ontologyBLASTP
247632224774491128R-2-hydroxyglutaryl-CoA dehydratase beta subunitQuickGO ontologyBLASTP
247744924786811233R-2-hydroxyglutaryl-CoA dehydratase alpha subunit familyQuickGO ontologyBLASTP
2478744247995812153-methyl-2-oxobutanoate dehydrogenase 2-methylpropanoyl-transferringQuickGO ontologyBLASTP
24806992481520822iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
2481921248319212722-hydroxyglutaryl-CoA dehydratase D-componentQuickGO ontologyBLASTP
248319524848861692benzoyl-CoA reductase subunit AQuickGO ontologyBLASTP
248518524863361152putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
24869202487519600hypothetical proteinBLASTP
24879362488529594acetyltransferase GNAT familyQuickGO ontologyBLASTP